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Growth factor and hypoxia-inducible factor alpha content in the retina of male Wistar rats in experimental diabetic retinopathy and the effect of cellular protein kinase blockade

BackgroundDiabetic retinopathy (DR) is a leading cause of vision loss in patients with diabetes mellitus (DM). Hypoxia-driven overexpression of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1α (HIF-1α) is central to diabetic retinopathy (DR) pathogenesis. The use of cellular...

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Tallennettuna:
Päätekijät: K. O. Usenko, Olena Strubchevska, S. O. Rykov, M. S. Babenko, Kateryna Strubchevska, Oleksandra Kozyk, S. V. Ziablitsev, Marko Kozyk
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2025-10-01
Sarja:Frontiers in Endocrinology
Aiheet:
diabetes mellitus
diabetic retinopathy
VEGF
HIF-1α
western blot
immunohistochemistry
Linkit:https://www.frontiersin.org/articles/10.3389/fendo.2025.1643445/full
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