Cluster minimal sufficient balance (CMSB): an efficient covariate balancing randomization method for cluster randomized trials

Abstract Background Cluster randomized trials (CRTs) require balanced baseline covariates to yield unbiased estimates of treatment effects. Existing approaches such as constrained randomization can improve balance but may compromise allocation randomness. We introduce Cluster Minimal Sufficient Bala...

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Autori principali:	Jiaxin Cai, Shanshan Suo, Valirie Ndip, Carole Khairallah, Binyan Zhang, Lingxia Zeng, Hong Yan, Fang Shao, Tao Chen, Chao Li
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2026-01-01
Serie:	BMC Medical Research Methodology
Soggetti:	Cluster randomized trial Covariates balance Randomization Cluster minimal sufficient balance Computational efficiency
Accesso online:	https://doi.org/10.1186/s12874-025-02758-0
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