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Proton induced DNA double strand breaks at the Bragg peak: Evidence of enhanced LET effect

PurposeTo investigate DNA double strand breaks (DSBs) induced by therapeutic proton beams in plateau and Bragg peak to demonstrate DSB induction due to the higher LET in the Bragg peak.Materials and MethodspUC19 plasmid DNA samples were irradiated to doses of 1000 and 3000 Gy on a Mevion S250i proto...

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Principais autores: Cara M. Frame, Yu Chen, Jonathan Gagnon, Y. Yuan, Tianjun Ma, Anatoly Dritschilo, Dalong Pang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-08-01
Serier:Frontiers in Oncology
Fag:
AFM
proton
Bragg peak
DNA
DSB
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2022.930393/full
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