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Proliferation of Genetically Modified Human Cells on Electrospun Nanofiber Scaffolds

Gene editing is a process by which single base mutations can be corrected, in the context of the chromosome, using single-stranded oligodeoxynucleotides (ssODNs). The survival and proliferation of the corrected cells bearing modified genes, however, are impeded by a phenomenon known as reduced proli...

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Autors principals: Mandula Borjigin, Bryan Strouse, Rohina A Niamat, Pawel Bialk, Chris Eskridge, Jingwei Xie, Eric B Kmiec
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2012-01-01
Col·lecció:Molecular Therapy: Nucleic Acids
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Accés en línia:http://www.sciencedirect.com/science/article/pii/S2162253116301172
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