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Fine-tuning affinity and spacer design enhances T cell potency in DLL3 and BCMA CAR T cells

Chimeric antigen receptor (CAR)-modified T cells have garnered substantial attention due to their clinical success, culminating in six Food and Drug Administration-approved therapies for hematological malignancies. Notably, CD19-specific CAR T cell therapies have achieved remarkable clinical efficac...

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Principais autores: Nicholas Mazzanti, Ninkka Tamot, Andrea Francese, Jinquan Luo, M. Jack Borrok, Julie Rossillo, Joseph Plummer, Gauri Anand Patwardhan, Chi Shing Sum, Michael Ports, Kara L. Spiller, Madhusudhanan Sukumar
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2026-12-01
Serier:mAbs
Fag:
Affinity
CAR
CAR design
chimeric antigen receptor
spacer domain
Online adgang:https://www.tandfonline.com/doi/10.1080/19420862.2025.2602989
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