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Human CD5+ Innate Lymphoid Cells Are Functionally Immature and Their Development from CD34+ Progenitor Cells Is Regulated by Id2

Innate lymphoid cells (ILCs) have emerged as a key cell type involved in surveillance and maintenance of mucosal tissues. Mouse ILCs rely on the transcriptional regulator Inhibitor of DNA-binding protein 2 (Id2) for their development. Here, we show that Id2 also drives development of human ILC becau...

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Autori principali: Maho Nagasawa, Kristine Germar, Bianca Blom, Hergen Spits
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2017-08-01
Serie:Frontiers in Immunology
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Accesso online:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01047/full
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