Within-host microevolution of Streptococcus pneumoniae is rapid and adaptive during natural colonisation

Streptococcus pneumoniae is an opportunistic pathogen and asymptomatic colonization is a precursor for invasive disease. Here the authors show rapid within-host evolution of naturally acquired pneumococci in ninety-eight infants driven by high nucleotide substitution rates and intra-host homologous...

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Bibliografiske detaljer

Principais autores:	Chrispin Chaguza, Madikay Senghore, Ebrima Bojang, Rebecca A. Gladstone, Stephanie W. Lo, Peggy-Estelle Tientcheu, Rowan E. Bancroft, Archibald Worwui, Ebenezer Foster-Nyarko, Fatima Ceesay, Catherine Okoi, Lesley McGee, Keith P. Klugman, Robert F. Breiman, Michael R. Barer, Richard A. Adegbola, Martin Antonio, Stephen D. Bentley, Brenda A. Kwambana-Adams
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2020-07-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-020-17327-w
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