Tocilizumab but not Siltuximab prevents systemic inflammation in a humanized mouse model

ObjectivesThe present study aimed to assess the therapeutic efficacy of neutralizing monoclonal antibodies targeting a prominent proinflammatory cytokine in a PBMC transfer-induced humanized mouse model of systemic inflammation.MethodsInflammatory cytokines were measured in human and murine sera usi...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Liang Zhang, Jacqueline Wax, Torsten Goldmann, Afsaneh Mehrpouyan, Antje Müller, Frank Petersen, Gabriela Riemekasten, Xinhua Yu
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Frontiers Media S.A. 2026-06-01
Sarja:	Frontiers in Immunology
Aiheet:	humanized mouse model Siltuximab systemic sclerosis therapeutic efficacy Tocilizumab systemic inflammation
Linkit:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1813955/full
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