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Epigenetic status of H19/IGF2 and SNRPN imprinted genes in aborted and successfully derived embryonic stem cell lines in non-human primates

The imprinted genes of primate embryonic stem cells (ESCs) often show altered DNA methylation. It is unknown whether these alterations emerge while deriving the ESCs. Here we studied the methylation patterns of two differentially methylated regions (DMRs), SNRPN and H19/IGF2 DMRs, during the derivat...

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Autors principals: Florence Wianny, Thierry Blachère, Murielle Godet, Rémi Guillermas, Véronique Cortay, Pierre-Yves Bourillot, Annick Lefèvre, Pierre Savatier, Colette Dehay
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2016-05-01
Col·lecció:Stem Cell Research
Matèries:
Embryonic stem cell
Non-human primate
Epigenetic
Imprinted genes
Methylation
H19/IGF2
SNRPN
Accés en línia:http://www.sciencedirect.com/science/article/pii/S1873506116000866
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