Gamma-secretase inhibition combined with platinum compounds enhances cell death in a large subset of colorectal cancer cells
<p>Abstract</p> <p>Background</p> <p>Notch signalling is essential for the development and maintenance of the colonic epithelium. Its inhibition induces a differentiation phenotype in vivo and reduces adenomas in APC<sup>min </sup>mice. Whether Notch signals are also required in colorectal cancer (C...
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| Principais autores: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BMC
2008-10-01
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| Serier: | Cell Communication and Signaling |
| Online adgang: | http://www.biosignaling.com/content/6/1/8 |
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