Ursodeoxycholic and chenodeoxycholic bile acids alleviate endotoxininduced acute lung injury in rats by modulating aquaporin expression and pathways associated with apoptosis and inflammation

IntroductionThis study aimed to investigate the anti-inflammatory, antioxidant, and anti-apoptotic properties of ursodeoxycholic (UDCA) and chenodeoxycholic (CDCA) bile acids in a rat model of endotoxin (lipopolysaccharide, LPS)-induced acute lung injury (ALI).MethodsThe study included six groups of...

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Autors principals:	Tatjana Milivojac, Milkica Grabež, Ljiljana Amidžić, Alma Prtina, Aleksandra Krivokuća, Ugljesa Malicevic, Maja Barudžija, Milka Matičić, Snežana Uletilović, Nebojša Mandić-Kovačević, Tanja Cvjetković, Miloš P. Stojiljković, Milica Gajić Bojić, Momir Mikov, Radoslav Gajanin, Sergey Bolevich, Aleksandar Petrović, Ranko Škrbić
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2025-03-01
Col·lecció:	Frontiers in Pharmacology
Matèries:	chenodeoxycholic acid ursodeoxycholic acid endotoxin acute lung injury oxidative stress inflammation
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1484292/full
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