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Disruption of chrna5 blunts aversion and adaptive transcriptomic responses to nicotine and alcohol

Summary: Addiction to nicotine and alcohol continues to be a leading cause of death and loss of productivity. Polymorphisms in CHRNA5 have been identified as risk factors in human genetic studies. Whether the CHRNA5 function is independently relevant to phenotypes associated with substance abuse and...

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Principais autores: Tanisha Goel, Joshua Raine, Caroline Kibat, Jeff Winxin Collado, Tirtha Das Banerjee, Ajay S. Mathuru
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2026-02-01
Serija:iScience
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Online dostop:http://www.sciencedirect.com/science/article/pii/S2589004226001100
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