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Topiramate suppresses peri-infarct spreading depolarization and improves outcomes in a rat model of photothrombotic stroke

Summary: Ischemic stroke can cause depolarized brain waves, termed peri-infarct depolarization (PID). Here, we evaluated whether topiramate, a neuroprotective drug used to treat epilepsy and alleviate migraine, has the potential to reduce PID. We employed a rat model of photothrombotic ischemia that...

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Asıl Yazarlar: Yuhling Wang, Shaoyu Yen, Yen-Yu Ian Shih, Chien-Wen Lai, Yu-Lin Chen, Li-Tzong Chen, Hsi Chen, Lun-De Liao
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2024-06-01
Seri Bilgileri:iScience
Konular:
Natural sciences
Biological sciences
Neuroscience
Physiology
Systems neuroscience
Molecular neuroscience
Online Erişim:http://www.sciencedirect.com/science/article/pii/S2589004224012586
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