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K+-Cl− cotransporter 1 (KCC1): a housekeeping membrane protein that plays key supplemental roles in hematopoietic and cancer cells

Abstract During the 1970s, a Na+-independent, ouabain-insensitive, N-ethylmaleimide-stimulated K+-Cl− cotransport mechanism was identified in red blood cells for the first time and in a variety of cell types afterward. During and just after the mid-1990s, three closely related isoforms were shown to...

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Main Authors: A. P. Garneau, S. Slimani, L. E. Tremblay, M. J. Fiola, A. A. Marcoux, P. Isenring
Format: Artigo
Language:Inglês
Published: BMC 2019-07-01
Series:Journal of Hematology & Oncology
Subjects:
Cation-Cl− cotransporter
K+-Cl− cotransporter
Red blood cells
Sickle cell anemia
Abnormal cell growth
Animal models
Online Access:http://link.springer.com/article/10.1186/s13045-019-0766-x
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