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Altered fatty acid metabolism rewires cholangiocarcinoma stemness features

Background & Aims: Among the reprogrammed metabolic pathways described in cancer stem cells, aberrant lipid metabolism has recently drawn increasing attention. Our study explored the contribution of fatty acids (FA) in the regulation of stem-like features in intrahepatic cholangiocarcinoma (iCCA...

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Main Authors: Giulia Lori, Mirella Pastore, Nadia Navari, Benedetta Piombanti, Richell Booijink, Elisabetta Rovida, Ignazia Tusa, Monika Lewinska, Jesper B. Andersen, Tiziano Lottini, Annarosa Arcangeli, Maria Letizia Taddei, Erica Pranzini, Caterina Mancini, Cecilia Anceschi, Stefania Madiai, Elena Sacco, Stefano Rota, Adriana Trapani, Gennaro Agrimi, Matteo Ramazzotti, Paola Ostano, Caterina Peraldo Neia, Matteo Parri, Fabrizia Carli, Silvia Sabatini, Amalia Gastaldelli, Fabio Marra, Chiara Raggi
Format: Artigo
Language:Inglês
Published: Elsevier 2024-10-01
Series:JHEP Reports
Subjects:
Hepatobiliary tumours
Cancer stem cells
Lipid metabolism
Oleic acid
Palmitoleic acid
triglycerides
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555924001861
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