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Advances in the Molecular Modification of Microbial ω-Transaminases for Asymmetric Synthesis of Bulky Chiral Amines

ω-Transaminases are biocatalysts capable of asymmetrically synthesizing high-value chiral amines through the reductive amination of carbonyl compounds, and they are ubiquitously distributed across diverse microorganisms. Despite their broad natural occurrence, the industrial utility of naturally occ...

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Principais autores: Xinxing Gao, Qingming He, Hailong Chen, Wangshui Cai, Long Xu, Xin Zhang, Nianqing Zhu, Shoushuai Feng
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2025-04-01
Serier:Microorganisms
Fag:
ω-transaminases
bulky chiral amines
molecular modification
protein engineering
Online adgang:https://www.mdpi.com/2076-2607/13/4/820
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