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Adeno-associated virus 2 CRISPR/Cas9-mediated targeting of hepatitis B virus in tree shrews

Chronic hepatitis B virus (HBV) infection is a global health issue with limited therapeutic options given the persistence of viral episomal DNA (cccDNA). Previously, we investigated the effects of adeno-associated virus 2 (AAV2) vector-mediated delivery of three guide (g)RNAs/Cas9 selected from 16 g...

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Principais autores: Md Haroon Or Rashid, Mohammad Enamul Hoque Kayesh, Md Abul Hashem, Tatsuro Hifumi, Shintaro Ogawa, Noriaki Miyoshi, Yasuhito Tanaka, Michinori Kohara, Kyoko Tsukiyama-Kohara
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-04-01
Serier:Virus Research
Fag:
Hepatitis B virus
HBV-F, CRISPR/Cas9
Adeno-associated virus 2
Northern tree shrew
Tupaia
Online adgang:http://www.sciencedirect.com/science/article/pii/S0168170225000267
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