Necroptosis-driven T cell activation promotes IL-6-mediated PD-L1 upregulation in cholangiocarcinoma cells: IL-6 gene signature as a biomarker for chemo-immunotherapy response

Abstract Background Cholangiocarcinoma (CCA) is an aggressive malignancy with limited treatment options. Despite the approval of chemotherapy and immune checkpoint inhibitors (ICIs) in clinical practice, treatment outcomes remain poor, largely due to the poorly immunogenic tumor microenvironment ass...

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Principais autores:	Thanpisit Lomphithak, Nattaya Duangthim, Sasiprapa Sonkaew, Siriporn Jitkaew
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-09-01
Colecção:	Biology Direct
Assuntos:	Cholangiocarcinoma Chemo-immunotherapy Necroptosis T cell activation Immune checkpoint inhibitors IL-6 signaling
Acesso em linha:	https://doi.org/10.1186/s13062-025-00687-y
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