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Reduction of lymphotoxin beta receptor induces cellular senescence via the MDMX-p53 pathway

Abstract The lymphotoxin β receptor (LTβR), a key activator of non-canonical NF-κB signaling, is expressed in various cells, including cancer cells. Although high expression of LTβR has been associated with poor patient prognosis and drug resistance, conflicting evidence suggested that LTβR induces...

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Príomhchruthaitheoirí: So Young Kim, Bin Lee, Je-Jung Lee, Man Sup Kwak, Woo Joong Rhee, In Ho Park, Jeon-Soo Shin
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Nature Publishing Group 2025-08-01
Sraith:Cell Death Discovery
Rochtain ar líne:https://doi.org/10.1038/s41420-025-02708-1
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