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Neuroglobin regulates autophagy through mTORC1/RAPTOR/ULK-1 pathway in human neuroblastoma cells

Abstract Neuroglobin (NGB) is a hexacoordinated hemeprotein mainly expressed in neurons. Following its upregulation and mitochondrial localization, NGB plays a pro-survival role against neuronal stress. Previously, we built a stable NGB-FLAG-overexpressing neuroblastoma cell line and showed that NGB...

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Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Valeria Manganelli, Michele Costanzo, Daniela Caissutti, Illari Salvatori, Niccolò Candelise, Emiliano Montalesi, Giovanna De Simone, Alberto Ferri, Tina Garofalo, Maurizio Sorice, Margherita Ruoppolo, Agostina Longo, Roberta Misasi
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Nature Portfolio 2025-03-01
Sraith:Scientific Reports
Ábhair:
Rochtain ar líne:https://doi.org/10.1038/s41598-025-91701-w
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