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Fragile X mental retardation protein expression in Alzheimer’s disease

The FMR1 protein product, FMRP, is an mRNA binding protein associated with translational inhibition of target transcripts. One FMRP target is the amyloid precursor protein (APP) mRNA, and APP levels are elevated in Fmr1 KO mice. Given that elevated APP protein expression can elicit Alzheimer’s dis...

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Príomhchruthaitheoirí: Abigail J Renoux, Nicholas M Carducci, Arya A Ahmady, Peter K Todd
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Frontiers Media S.A. 2014-10-01
Sraith:Frontiers in Genetics
Ábhair:
Rochtain ar líne:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00360/full
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