Dichloroacetate, an inhibitor of pyruvate dehydrogenase kinases, inhibits platelet aggregation and arterial thrombosis

Abstract: Resting platelets rely on oxidative phosphorylation (OXPHOS) and aerobic glycolysis (conversion of glucose to lactate in the presence of oxygen) to generate adenosine triphosphate, whereas activated platelets exhibit a high level of aerobic glycolysis, suggesting the existence of metabolic...

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Hauptverfasser:	Manasa K. Nayak, Nirav Dhanesha, Prakash Doddapattar, Omar Rodriguez, Vijay K. Sonkar, Sanjana Dayal, Anil K. Chauhan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2018-08-01
Schriftenreihe:	Blood Advances
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2473952920309198
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