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The role of Mesothelin signaling in Portal Fibroblasts in the pathogenesis of cholestatic liver fibrosis

Liver fibrosis develops in response to chronic toxic or cholestatic injury, and is characterized by apoptosis of damaged hepatocytes, development of inflammatory responses, and activation of Collagen Type I producing myofibroblasts that make liver fibrotic. Two major cell types, Hepatic Stellate Cel...

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Detalhes bibliográficos
Principais autores: Hiroaki Fuji, Grant Miller, Takahiro Nishio, Yukinori Koyama, Kevin Lam, Vivian Zhang, Rohit Loomba, David Brenner, Tatiana Kisseleva
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-12-01
coleção:Frontiers in Molecular Biosciences
Assuntos:
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fmolb.2021.790032/full
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