Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function

Abstract α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase that maintains the catalytic function of α-ketoglutarate dehydrogenase (α-KGDH), and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis (RA). However, the importance of...

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Principais autores:	Benjamin J. Jenkins, Yasmin R. Jenkins, Fernando M. Ponce-Garcia, Chloe Moscrop, Iain A. Perry, Matthew D. Hitchings, Alejandro H. Uribe, Federico Bernuzzi, Simon Eastham, James G. Cronin, Ardena Berisha, Alexandra Howell, Joanne Davies, Julianna Blagih, Marta Williams, Morgan Marsden, Douglas J. Veale, Luke C. Davies, Micah Niphakis, David K. Finlay, Linda V. Sinclair, Benjamin F. Cravatt, Andrew E. Hogan, James A. Nathan, Ian R. Humphreys, Ursula Fearon, David Sumpton, Johan Vande Voorde, Goncalo Dias do Vale, Jeffrey G. McDonald, Gareth W. Jones, James A. Pearson, Emma E. Vincent, Nicholas Jones
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-11-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-025-65417-4
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