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Sumoylation of the Carboxy-Terminal of Human Cytomegalovirus DNA Polymerase Processivity Factor UL44 Attenuates Viral DNA Replication

Controlled regulation of genomic DNA synthesis is a universally conserved process for all herpesviruses, including human cytomegalovirus (HCMV), and plays a key role in viral pathogenesis, such as persistent infections. HCMV DNA polymerase processivity factor UL44 plays an essential role in viral DN...

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Principais autores: Jun Chen, Guanlie Li, Haiqing He, Xin Li, Wenjing Niu, Di Cao, Ao Shen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-04-01
Colecção:Frontiers in Microbiology
Assuntos:
human cytomegalovirus
UL44
sumoylation
DNA replication
UBC9
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fmicb.2021.652719/full
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