Deletion of the Wilms’ Tumor Suppressor Gene in the Cardiac Troponin-T Lineage Reveals Novel Functions of WT1 in Heart Development

Expression of Wilms’ tumor suppressor transcription factor (WT1) in the embryonic epicardium is essential for cardiac development, but its myocardial expression is little known. We have found that WT1 is expressed at low levels in 20–25% of the embryonic cardiomyocytes. Conditional ablation of WT1 u...

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Bibliografische Detailangaben

Hauptverfasser:	Sandra Díaz del Moral, Silvia Barrena, Francisco Hernández-Torres, Amelia Aránega, José Manuel Villaescusa, Juan José Gómez Doblas, Diego Franco, Manuel Jiménez-Navarro, Ramón Muñoz-Chápuli, Rita Carmona
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2021-07-01
Schriftenreihe:	Frontiers in Cell and Developmental Biology
Schlagworte:	Wilms’ tumor suppressor gene cardiomyocytes cardiac development calcium homeostasis potassium channels
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fcell.2021.683861/full
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