The role of TDP-43 fragments in regular cellular functions and homeostatic failure

Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of motor neurons, leading to severe muscle weakness, loss of voluntary movement, and respiratory failure. A widely noted feature of the disease is the presence of TDP-43 proteinopathies. Under homeostatic conditions...

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Autors principals:	Regina Dahlhaus, Ralf J. Braun
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2026-05-01
Col·lecció:	Neurobiology of Disease
Matèries:	Amyotrophic lateral sclerosis TDP-43 proteinopathies TDP-43 fragments Proteases Neuronal function Glial function
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S096999612600094X
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