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Prospects for the computational humanization of antibodies and nanobodies

To be viable therapeutics, antibodies must be tolerated by the human immune system. Rational approaches to reduce the risk of unwanted immunogenicity involve maximizing the ‘humanness’ of the candidate drug. However, despite the emergence of new discovery technologies, many of which start from entir...

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Autores principales: Gemma L. Gordon, Matthew I. J. Raybould, Ashley Wong, Charlotte M. Deane
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2024-05-01
Colección:Frontiers in Immunology
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Acceso en línea:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1399438/full
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