SNF2L maintains glutathione homeostasis by initiating SLC7A11 transcription through chromatin remodeling
Abstract SNF2L encodes an ISWI chromatin remodeling factor that promotes gene transcription and is consistently elevated in cancers. Previous studies have shown that inhibiting SNF2L expression in cancer cells leads to significant growth suppression, DNA damage, and cell death. However, the underlyi...
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| Hauptverfasser: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2024-11-01
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| Schriftenreihe: | Cell Death and Disease |
| Online-Zugang: | https://doi.org/10.1038/s41419-024-07221-4 |
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