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A bitopic mTORC inhibitor reverses phenotypes in a tuberous sclerosis complex model

Abstract Neural stem cells (NSCs) of the ventricular-subventricular zone (V-SVZ) generate diverse cell types including striatal glia during the neonatal period. NSC progeny uncouple stem cell-related mRNA transcripts from being translated during differentiation. We previously demonstrated that Tsc2...

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Bibliografische Detailangaben
Hauptverfasser: Sulagna Mukherjee, Matthew J. Wolan, Mary K. Scott, Victoria A. Riley, Aidan M. Sokolov, David M. Feliciano
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2025-07-01
Schriftenreihe:Scientific Reports
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Online-Zugang:https://doi.org/10.1038/s41598-025-08345-z
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