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Importance of CD200 expression by tumor or host cells to regulation of immunotherapy in a mouse breast cancer model.

Cell-surface CD200 expression by mouse EMT6 breast tumor cells increased primary tumor growth and metastasis to the draining lymph nodes (DLN) in normal (WT) BALB/c female recipients, while lack of CD200R1 expression in a CD200R1-/- host negated this effect. Silencing CD200 expression in EMT6siCD200...

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Principais autores: Anna Curry, Ismat Khatri, Olha Kos, Fang Zhu, Reginald Gorczynski
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2017-01-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC5325206?pdf=render
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