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PAD-Beads enrichment enhances detection of PrPSc using real-time quaking-induced conversion

Abstract Objective Scrapie is a transmissible spongiform encephalopathy (TSE) that naturally occurs in sheep and goats. This fatal neurodegenerative disease results from misfolding of the normal cellular prion protein (PrPC) to a pathogenic prion protein form (PrPSc). This pathogenic form, PrPSc, ac...

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Principais autores: Soyoun Hwang, Rohana P. Dassanayake, Eric M. Nicholson
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2019-12-01
Serier:BMC Research Notes
Fag:
Scrapie
Prion diseases
RT-QuIC
Transmissible spongiform encephalopathy
PAD-Beads
Magnetic particle extraction
Online adgang:https://doi.org/10.1186/s13104-019-4842-7
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