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β-Arrestin1 Reduces Oxidative Stress via Nrf2 Activation in the Rostral Ventrolateral Medulla in Hypertension

Oxidative stress in the rostral ventrolateral medulla (RVLM), a key region for blood pressure (BP) regulation, has been demonstrated to be responsible for the overactivity of the sympathetic nervous system in hypertension and heart failure. Nuclear factor-erythroid-2-related factor 2 (Nrf2) is a key...

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Principais autores: Xing Tan, Pei-Lei Jiao, Jia-Cen Sun, Wen Wang, Peng Ye, Yang-Kai Wang, Yue-Qi Leng, Wei-Zhong Wang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-04-01
Serier:Frontiers in Neuroscience
Fag:
hypertension
rostral ventrolateral medulla
β-arrestin1
oxidative stress
Nrf2
Online adgang:https://www.frontiersin.org/articles/10.3389/fnins.2021.657825/full
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