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Non-pathogenic microbiota accelerate age-related CpG Island methylation in colonic mucosa

DNA methylation is an epigenetic process altered in cancer and ageing. Age-related methylation drift can be used to estimate lifespan and can be influenced by extrinsic factors such as diet. Here, we report that non-pathogenic microbiota accelerate age-related methylation drift in the colon when com...

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Principais autores: Ang Sun, Pyounghwa Park, Lauren Cole, Himani Vaidya, Shinji Maegawa, Kelsey Keith, Gennaro Calendo, Jozef Madzo, Jaroslav Jelinek, Christian Jobin, Jean-Pierre J. Issa
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis Group 2023-12-01
Series:Epigenetics
Assuntos:
dna methylation
microbiota
germ-free
inflammation
ageing
Acceso en liña:http://dx.doi.org/10.1080/15592294.2022.2160568
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