Precision engineering of the probiotic Escherichia coli Nissle 1917 with prime editing

ABSTRACT CRISPR-Cas systems are transforming precision medicine with engineered probiotics as next-generation diagnostics and therapeutics. To promote human health and treat disease, engineering probiotic bacteria demands maximal versatility to enable non-natural functionalities while minimizing und...

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Hauptverfasser: Pei-Ru Chen, Ying Wei, Xin Li, Hai-Yan Yu, Shu-Guang Wang, Xian-Zheng Yuan, Peng-Fei Xia
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2025-02-01
Schriftenreihe:Applied and Environmental Microbiology
Schlagworte:
CRISPR
prime editing
probiotics
Escherichia coli Nissle 1917
Online Zugang:https://journals.asm.org/doi/10.1128/aem.00031-25
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