Novel tri-specific tribodies induce strong T cell activation and anti-tumor effects in vitro and in vivo

Abstract Background Immunotherapy based on Bi-specific T Cell Engagers (TCE) represents one of the most attractive strategy to treat cancers resistant to conventional therapies. TCE are antibody-like proteins that simultaneously bind with one arm to a Tumor Associated Antigen (TAA) on cancer cells a...

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Detalhes bibliográficos

Principais autores:	Margherita Passariello, Asami Yoshioka, Kota Takahashi, Shu-ichi Hashimoto, Toshikazu Inoue, Koji Nakamura, Claudia De Lorenzo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-09-01
Colecção:	Journal of Experimental & Clinical Cancer Research
Assuntos:	Immunotherapy Bi-Specific T Cell Engager Tri-Specific Tribodies Immune Checkpoints Cancer
Acesso em linha:	https://doi.org/10.1186/s13046-022-02474-3
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