Cigarette Tar Enhanced ECs Pyroptosis via CAMKII/Drp1/mtDNA

Summary: Smoking is the only cardiovascular risk factor for plaque erosion. We found cigarette tar resulted in erosion-like lesion development in apolipoprotein E−/− mice, with mural thrombosis, discontinuous endothelium, platelet activation, smooth muscle cell proliferation, and hyaluronic acid acc...

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Autors principals:	Xing Luo, PhD, Ji Li, PhD, Yuwu Chen, MD, Xiuzhu Weng, MD, Xiaoyi Bao, PhD, Xiaoxuan Bai, MD, Ying Lv, PhD, Shan Zhang, PhD, Xinxin Zhu, MD, Biyi Xu, MD, Chen Zhao, MD, Ming Zeng, MD, Tianyu Wu, MD, Qianhui Sun, MD, Shengfang Wang, PhD, Minghao Liu, MD, Thomas Johnson, PhD, Stephen J. White, PhD, Peter Libby, MD, Sining Hu, PhD, Bo Yu, PhD, Haibo Jia, PhD
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-08-01
Col·lecció:	JACC: Basic to Translational Science
Matèries:	cigarette tar endothelial cells plaque erosion pyroptosis
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2452302X25001676
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