Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase

T7 RNA polymerase (RNAP) is widely used for synthesizing RNA molecules with synthetic modifications and unnatural base pairs (UBPs). Here, authors show the structural basis of how UBPs are recognized as template and substrate, providing mechanistic insights into UBP transcription by T7 RNAP.

Manylion Llyfryddiaeth

Prif Awduron:	Juntaek Oh, Michiko Kimoto, Haoqing Xu, Jenny Chong, Ichiro Hirao, Dong Wang
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Nature Portfolio 2023-01-01
Cyfres:	Nature Communications
Mynediad Ar-lein:	https://doi.org/10.1038/s41467-022-35755-8
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