The multiple faces of cGAS-STING in antitumor immunity: prospects and challenges
As a key sensor of double-stranded DNA (dsDNA), cyclic GMP-AMP synthase (cGAS) detects cytosolic dsDNA and initiates the synthesis of 2′3′ cyclic GMP-AMP (cGAMP) that activates the stimulator of interferon genes (STING). This finally promotes the production of type I interferons (IFN-I) that is cruc...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
De Gruyter
2024-06-01
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| Серии: | Medical Review |
| Предметы: | |
| Online-ссылка: | https://doi.org/10.1515/mr-2023-0061 |
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