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Functional and Proteomic Analysis of Streptococcus pyogenes Virulence Upon Loss of Its Native Cas9 Nuclease

The public health impact of Streptococcus pyogenes (group A Streptococcus, GAS) as a top 10 cause of infection-related mortality in humans contrasts with its benefit to biotechnology as the main natural source of Cas9 nuclease, the key component of the revolutionary CRISPR-Cas9 gene editing platform...

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Principais autores: Nina J. Gao, Mahmoud M. Al-Bassam, Saugat Poudel, Jacob M. Wozniak, David J. Gonzalez, Joshua Olson, Karsten Zengler, Victor Nizet, J. Andrés Valderrama
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019-08-01
Serier:Frontiers in Microbiology
Fag:
group A Streptococcus
Streptococcus pyogenes
CRISPR-Cas
Cas9
regulation
proteomics
Online adgang:https://www.frontiersin.org/article/10.3389/fmicb.2019.01967/full
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