PRDM16 expression is an independent prognostic factor in AML with the double-mutant NPM1/FLT3-ITD genotype

Abstract PRDM16 (PR Domain Containing 16) is a transcription factor that plays a critical role in hematopoietic stem cell maintenance. In acute myeloid leukemia (AML), PRDM16 overexpression is linked to specific cytogenetic risk groups and poor prognosis. However, in NPM1-mutated AMLs, PRDM16 expres...

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Autori principali:	Sebastian Stasik, Jan-Niklas Eckardt, Christoph Röllig, Claudia D. Baldus, Hubert Serve, Carsten Müller-Tidow, Kerstin Schäfer-Eckart, Martin Kaufmann, Stefan W. Krause, Mathias Hänel, Andreas Neubauer, Gerhard Ehninger, Uwe Platzbecker, Martin Bornhäuser, Johannes Schetelig, Jan M. Middeke, Christian Thiede
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Springer 2026-01-01
Serie:	Annals of Hematology
Soggetti:	PRDM16 expression Acute Myeloid Leukemia (AML) Clinical Outcome Molecular associations
Accesso online:	https://doi.org/10.1007/s00277-026-06767-x
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