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Astrocyte TrkB promotes brain injury and edema formation in ischemic stroke

Following ischemic stroke astrocytes undergo rapid molecular and functional changes that may accentuate tissue damage. In this study we identified the neurotrophin receptor TrkB in astrocytes as a key promoter of acute CNS injury in ischemic stroke. In fact, TrkB protein was strongly upregulated in...

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Principais autores: Emanuela Colombo, Marco Bacigaluppi, Michela Bartoccetti, Daniela Triolo, Claudia Bassani, Andrea Bergamaschi, Hélène C. Descamps, Giorgia Serena Gullotta, Maria Henley, Marco Piccoli, Luigi Anastasia, David Pitt, Jia Newcombe, Gianvito Martino, Cinthia Farina
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-10-01
Colecção:Neurobiology of Disease
Assuntos:
AQP4
Astrocyte
Stroke
TrkB
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0969996124002705
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