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CDK4/6 inhibitors: a novel strategy for tumor radiosensitization

Abstract Recently, the focus of enhancing tumor radiosensitivity has shifted from chemotherapeutics to targeted therapies. Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are a novel class of selective cell cycle therapeutics that target the cyclin D-CDK4/6 complex and induce G1 phase arrest. Th...

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Библиографические подробности
Главные авторы: Yilan Yang, Jurui Luo, Xingxing Chen, Zhaozhi Yang, Xin Mei, Jinli Ma, Zhen Zhang, Xiaomao Guo, Xiaoli Yu
Формат: Artigo
Язык:Inglês
Опубликовано: BMC 2020-09-01
Серии:Journal of Experimental & Clinical Cancer Research
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Online-ссылка:http://link.springer.com/article/10.1186/s13046-020-01693-w
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