Pregnane X Receptor‒4β‐Hydroxycholesterol Axis in the Regulation of Overweight‐ and Obesity‐Induced Hypertension

Background Mechanisms mediating hypertensive effects of overweight and obesity have not been fully elucidated. We showed previously that activation of pregnane X receptor (PXR) by rifampicin elevates 24‐hour blood pressure (BP) and plasma 4β‐hydroxycholesterol (4βHC), agonist for liver X receptor (L...

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Autores principales:	Roosa Rahunen, Outi Kummu, Vesa Koivukangas, Heidi Hautajärvi, Jukka Hakkola, Jaana Rysä, Janne Hukkanen
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Wiley 2022-03-01
Colección:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Materias:	4β‐hydroxycholesterol blood pressure liver X receptor obesity pregnane X receptor
Acceso en línea:	https://www.ahajournals.org/doi/10.1161/JAHA.121.023492
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