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Effect of intravenous fluid volume on biomarkers of endothelial glycocalyx shedding and inflammation during initial resuscitation of sepsis

Abstract Purpose To investigate the effect of IV fluid resuscitation on endothelial glycocalyx (EG) shedding and activation of the vascular endothelium and inflammation. Materials and methods A planned biomarker sub-study of the REFRESH trial in which emergency department (ED) patients) with suspect...

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Principais autores: Stephen Macdonald, Erika Bosio, Gerben Keijzers, Sally Burrows, Moira Hibbs, Helen O’Donoghue, David Taylor, Ashes Mukherjee, Frances Kinnear, Lisa Smart, Juan-Carlos Ascencio-Lane, Edward Litton, John Fraser, Nathan I. Shapiro, Glenn Arendts, Daniel Fatovich, The REFRESH Trial Investigators
Formato: Artigo
Idioma:Inglês
Publicado em: SpringerOpen 2023-04-01
coleção:Intensive Care Medicine Experimental
Assuntos:
Sepsis
Fluid therapy
Endothelium
Endothelial glycocalyx
Inflammation
Acesso em linha:https://doi.org/10.1186/s40635-023-00508-4
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