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MRNIP condensates promote DNA double-strand break sensing and end resection

The MRN complex is a critical sensor and processor of DNA double-strand breaks (DSBs). Here, the authors show that MRNIP forms liquid-like condensates to accelerate the MRN-mediated sensing and end resection of DSB, thereby promoting DSB repair.

Gorde:
Egile Nagusiak: Yun-Long Wang, Wan-Wen Zhao, Shao-Mei Bai, Li-Li Feng, Shu-Ying Bie, Li Gong, Fang Wang, Ming-Biao Wei, Wei-Xing Feng, Xiao-Lin Pang, Cao-Litao Qin, Xin-Ke Yin, Ying-Nai Wang, Weihua Zhou, Daniel R. Wahl, Quentin Liu, Ming Chen, Mien-Chie Hung, Xiang-Bo Wan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Portfolio 2022-05-01
Saila:Nature Communications
Sarrera elektronikoa:https://doi.org/10.1038/s41467-022-30303-w
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