Rebalancing TGF‐β/Smad7 signaling via Compound kushen injection in hepatic stellate cells protects against liver fibrosis and hepatocarcinogenesis

Abstract Background Liver fibrosis and fibrosis‐related hepatocarcinogenesis are a rising cause for morbidity and death worldwide. Although transforming growth factor‐β (TGF‐β) is a critical mediator of chronic liver fibrosis, targeting TGF‐β isoforms and receptors lead to unacceptable side effect....

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Detalhes bibliográficos

Principais autores:	Yang Yang, Mayu Sun, Weida Li, Chaobao Liu, Zheshun Jiang, Pengfei Gu, Jingquan Li, Wei Wang, Rongli You, Qian Ba, Xiaoguang Li, Hui Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2021-07-01
coleção:	Clinical and Translational Medicine
Assuntos:	Compound kushen injection hepatocellular carcinoma liver fibrosis TGF‐β/Smad signaling traditional chinese medicine
Acesso em linha:	https://doi.org/10.1002/ctm2.410
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