Shotgun metagenomic analysis reveals taxonomic and functional alterations in the gut microbiome across prodromal and symptomatic Lewy body disease

BackgroundLewy body disease (LBD) is a progressive neurodegenerative a-synucleinopathy, whereas isolated REM sleep behavior disorder (iRBD) is recognized as a prodromal stage of LBD. Although growing evidence implicates the gut–brain axis in neurodegeneration, the taxonomic and functional roles of t...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Xiaowei Zhao, Stuart J. McCarter, Vinod K. Gupta, Kiera M. Grant, Erik K. St. Louis, Kejal Kantarci, Rodolfo Savica, Max Hill, Helen E. Vuong, Christopher Staley, Bradley F. Boeve, Owen A. Ross, Levi M. Teigen, Jaeyun Sung
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-07-01
Schriftenreihe:	Frontiers in Microbiomes
Schlagworte:	dementia gut microbiome gut-brain axis isolated REM sleep behavior disorder (iRBD) Lewy body disease (LBD) mild cognitive impairment (MCI)
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/frmbi.2026.1834726/full
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