Hereditary Spastic Paraplegia: From Genes, Cells and Networks to Novel Pathways for Drug Discovery

Hereditary spastic paraplegia (HSP) is a diverse group of Mendelian genetic disorders affecting the upper motor neurons, specifically degeneration of their distal axons in the corticospinal tract. Currently, there are 80 genes or genomic loci (genomic regions for which the causative gene has not bee...

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Detalles Bibliográficos

Autor principal:	Alan Mackay-Sim
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2021-03-01
Colección:	Brain Sciences
Materias:	neurodegeneration motor neuron disease spastic paraplegia endoplasmic reticulum protein-protein interaction network
Acceso en línea:	https://www.mdpi.com/2076-3425/11/3/403
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