Total Synthesis of 8-Hydroxy-dihydroergotamine, the Major Human Metabolite of Dihydroergotamine

8-Hydroxy-dihydroergotamine is the major human metabolite of the anti-migraine drug dihydroergotamine and is required, along with a stable isotope-labelled derivative, to aid metabolic studies. An efficient, scalable synthesis of the unlabelled compound is described via the coupling of dihydrolyserg...

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Bibliografiske detaljer

Principais autores:	Manuel Monerris Mascaro, Alistair P. Henderson, Marta Drozdowska, Rachel Richardson, Dylan Nagel-Savage, Michael J. Hall, Alexandra Longcake, Lina Mardiana, Bernard T. Golding
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI AG 2026-05-01
Serier:	Molecules
Fag:	8-hydroxy-dihydroergotamine pentadeutero-8-hydroxy-dihydroergotamine synthesis stereochemistry dihydroergotamine metabolism
Online adgang:	https://www.mdpi.com/1420-3049/31/9/1547
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